"In the year that King Uzziah died, I saw the Lord sitting on a throne, high and lifted up, and the train of His robe filled the temple.  Above it stood seraphim; each one had six wings; with two he covered his face, with two he covered his feet, and with two he flew.  And one cried to another and said:  'Holy, holy, holy is the Lord of hosts; the whole earth is full of His glory!"  And the posts of the door were shaken by the voice of him who cried out, and the house was filled with smoke.  Then I said: "Woe is me, for I am undone!  Because I am a man of unclean lips, and I dwell in the midst of a people of unclean lips; for my eyes have seen the King, the Lord of hosts.'  Then one of the seraphim flew to me, having in his had a live coal which he had taken with the tongs from the altar;  And he touched my mouth with it, and said:  'Behold, this has touched your lips; your iniquity is taken away, and your sin purged.'  Also I heard the voice of the Lord saying:  'Whom shall I send, and who will go for us?'  Then I said, 'Here am I, send me.'   
Isaiah 6:1-8

Times of crisis and uncertainty can often bring people to a time of thought, a time of reflection, a time of worry & stress, and even a time of prayer.  This was such times that Isaiah found himself in.  King Uzziah's reign had begun with promise, but he succumbed to pride and presumed to be able to take on the duties assigned to the priests only.  Uzziah was suddenly struck with leprosy while he was offering incense at the altar and died in that condition.

Any crisis in our lives, however small, can be an opportunity for a fresh vision from the Lord.